One reason why women are at much greater risk of a major heart attack is that smoking may lower their levels of oestrogen, which has been shown to protect against narrowing of the arteries.
from Health24 News https://www.health24.com/Medical/Heart/Smoking-and-your-heart/why-young-female-smokers-could-be-at-much-greater-risk-of-a-major-heart-attack-20191007-2
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